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Martin J Weissenborn

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Open access Oct 2026

Regiodivergent Oxyfuctionalization of Non-natural Tricyclic Terpenoids Using Sequence Divergent Unspecific Peroxygenases (UPOs)

Unspecific peroxygenases (UPOs) catalyze the H2O2-dependent monooxygenation of organic substrates with regioselectivity and chemoselectivity; however, their application to sterically demanding, non-natural terpene skeletons has remained largely unexplored to date. Here, we present a computationally-guided, multiparam...

Lena Fraedrich, Bonnie Winter, Ahmed Hassanin et al. · 0 citations
Open access Jul 2026

Combining Stability-Centered Atomistic Design with Machine Learning for Targeted Enzyme Optimization

A machine-learning-assisted enzyme-engineering (MLEE) workflow that adds substrate-specific functional information to htFuncLib through an initial screening and sequencing round that may bypass the need for transition-state models and reduce the effort required for obtaining high-activity variants.

Li Wan, Mahdi Bagherpoor Helabad, Lena Fraedrich et al. · 0 citations

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