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Martina D'Angelo

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Open access Sep 2026

Bayesian Shrinkage Versus Frequentist Variable Selection in Small-Sample Translational Research: A Monte Carlo Simulation Study Grounded in Regenerative Medicine Biomarker Discovery

Introduction. Observational studies in regenerative medicine represent a promising frontier for the discovery of predictive biomarkers of therapeutic response, yet are structurally constrained by small sample sizes. This low-sample-size regime exposes variable selection methods to a high risk of overfitting and false d...

Michele Francesco Di Tolla, Domenico Iervolino, Vittorio Scisciola et al. · 0 citations

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