Marvin J. Miller

An in vitro comparative study of cefiderocol, siderophore-aztreonam and siderophore-daptomycin conjugates against select gram-negative bacteria.

Multidrug-resistant (MDR) Gram-negative bacteria pose significant therapeutic challenges due to their protective outer membranes and evolving resistance mechanisms. Exploiting bacterial iron uptake pathways via siderophore-antibiotic conjugates offers a promising strategy to enhance antibiotic efficacy. Here we synthes...