Richter transformation (RT) is an aggressive lymphoma that arises in patients with chronic lymphocytic leukemia (CLL), most commonly diffuse large B-cell lymphoma (DLBCL-RT). Outcomes remain poor with conventional chemoimmunotherapy, reflecting the role of increased genomic instability and impaired DNA repair in the pa...
Jian Li, Mark R. Dowling, Constantine S. Tam et al.· Blood Advances· 0 citations
BACKGROUND
Infection is the leading cause of non-relapse mortality after CAR-T therapy, yet individual risk prediction remains challenging. This exploratory study evaluated immune correlates of infection and other treatment-emergent adverse events in patients with diffuse large B-cell lymphoma (DLBCL) receiving CAR-T....
Gemma K. Reynolds, Lewis J. Williams, Göknur Giner et al.· Journal of Infection· 0 citations
The clinical utility of routine monitoring of chimeric antigen receptor (CAR) T-cell expansion post-infusion remains controversial. We conducted a retrospective analysis of a prospectively collected cohort of 176 patients with relapsed/refractory large B-cell lymphoma (LBCL) treated with axicabtagene ciloleucel (axi-ce...
Brydon Panozzo, S. Robinson, A. Minson et al.· British Journal of Haematolo...· 0 citations
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