Author

Maryam Mohammadi Khanaposhtani

2 papers indexed here

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Open access Sep 2026

Design and synthesis of carbazole–acrylamide–pyridinium hybrids as dual acetylcholinesterase/butyrylcholinesterase inhibitors and evaluation of their cytotoxic profile on SH-SY5Y and HEK293 cell lines

A novel series of seventeen carbazole–acrylamide–pyridinium-N-phenylacetamide hybrids (12a–q) was designed and synthesized as dual inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) for potential Alzheimer's disease therapy. Their inhibitory activity was evaluated against both enzymes using tacr...

A. Taherkhani, Halil Şenol, Y. Valizadeh et al. · RSC Medicinal Chemistry · 0 citations

Oct 2026

New hybrid molecules with 2,3,4,9-tetrahydro-1H-carbazol-1,3,4-oxadiazole-N-phenylacetamide framework as potent cholinesterase inhibitors.

AIMS In this study, new 2,3,4,9-tetrahydro-1H-carbazol-1,3,4-oxadiazole-N-phenylacetamide hybrids 8a-n as potential dual inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) for the treatment of Alzheimer's disease (AD) were introduced. METHODS The target compounds were designed using a molecula...

Reza Hassanzadeh Dostkoh, Navid Dastyafteh, Aida Iraji et al. · Future Medicinal Chemistry · 0 citations