Open access
Jul 2026
Architectural chromatin interactions provide a framework for context-dependent gene regulation
A biologically informed framework for classifying and interpreting chromatin interactions is developed and dual-state regulatory elements connected to these dual-state regulatory elements are enriched for developmental and signaling pathways and exhibit increased expression specificity across cell types, consistent with specialized roles in context-dependent gene regulation.
Maryel Likhite, Gregory Andrews, Mingshi Gao et al.
· bioRxiv · 0 citations