Author

Masahide Yano

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Open access Oct 2026

In vitro activity and comparative efficacy of novel nitrofuran-containing ciprofloxacin analogs against bacterial pathogens including ciprofloxacin-resistant Staphylococcus aureus.

The rapid rise of antimicrobial resistance, especially in Staphylococcus aureus, highlights the urgent need for improved antibacterial agents. In 2019 alone, AMR caused an estimated 1.27 million deaths and contributed to nearly 5 million more globally. Here, we present the design, synthesis, and testing of modified cip...

Kate Marshall, Patricia A. Miller, Reilly M. Coates et al. · Journal of antibiotics (Toky... · 0 citations

Open access Aug 2026

Carbamazepine activates private self and viral reactive TCRs through a drug-permissive HLA-B cleft

Introduction Carbamazepine (CBZ) can cause severe cutaneous adverse reactions, including Stevens-Johnson syndrome/toxic epidermal necrolysis, and is strongly associated with HLA risk alleles. However, HLA genotype alone incompletely predicts clinical risk. Adverse drug reactions depend on drug-peptide-HLA conformation,...

SuJin Hwang, Masahide Yano, Yura Jang et al. · Frontiers in Immunology · 0 citations