Nanomaterials have attracted considerable attention owing to their unique physicochemical and optical properties and have been actively explored for a wide range of biological and biomedical applications. In particular, optical nanomaterials, including plasmonic nanoparticles, quantum dots, and upconversion nanoparti...
Tomoko Inose, Masahiko Yoshimura· Bulletin of the Chemical Soc...· 0 citations
Chemical kinetics has long inferred local molecular behaviour through the flask-and-molarity pairing, where well-mixed concentrations serve as the experimental readout. Yet many biological reactions occur in structured environments. Researchers have long recognized that concentration may not carry the same operational...
Fuyuki Matsuda, Masahiko Yoshimura, S. Ikeda et al.· 0 citations
The affinity-and-geometry readout enabled rational screening for protein-protein-interaction modulators, identifying compounds that enhance weak associations by reweighting local encounters rather than binding tightly on their own or forming a stable ternary complex.
Masahiko Yoshimura, Fuyuki Matsuda, Yoshiki Ikeda et al.· 0 citations
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