Open access
Oct 2026
Molecular mechanism of SIRT1 activation by polymethoxyflavonoids derived from citrus peels.
Sirtuin 1 (SIRT1) activation by small molecules is linked to aging-related health benefits. We investigated how citrus peel-derived polymethoxyflavonoids (PMFs), 3,5,6,7,8,3',4'-heptamethoxyflavone (HMF) and 5,6,7,8,3',4'-hexamethoxyflavone (nobiletin), activate SIRT1. Both compounds modestly but reproducibly increased...
D. Warman, Koh Takeuchi, Sayaka Okonogi et al.
· Food Chemistry · 0 citations