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Author

Masayuki Sugimoto

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Jul 2026

Optimized Chemical Modifications Enhance Lipid Nanoparticle-Mediated siRNA Silencing of YAP1 and WWTR1

Advanced sequence-modification patterns in siRNAs targeting YAP1 and WWTR1 achieved superior knockdown efficacy in vivo compared with partially modified LNP-siRNAs typically used in clinical drugs, providing a framework for chemical optimization of LNP-based siRNAs.

Kaito Ueda, Tatsuki Sato, Jumpei Sasaki et al. · 0 citations

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