Masayuki X. Mori

Atomistic Insights into TRPC6–Caveolin-1 Interactions Interface via All-Atom Molecular Dynamics Simulations: Structural and Energetic Basis for Selective Modulation

The molecular determinants governing TRPC6 stabilization and its interaction with caveolin-1 (CAV1) remain poorly defined, despite their critical role in caveolae organization and signaling. The absence of atomistic structural models has hindered a mechanistic understanding of how TRPC6 is recruited to, and stabilized...