Open access
Sep 2026
Inter-domain distance analysis reveals conformational changes in the Keap1-Nrf2 stress sensor system
The Keap1-Nrf2 system plays a central role in cellular defense against oxidative stress. Structural information on full-length Keap1 is essential for understanding the molecular basis of this regulation. However, its overall architecture has remained elusive due to pronounced conformational flexibility. In this study,...
Ritsumi Saito, Takeshi Kawabata, S. Yamashita et al.
· Redox Biology · 0 citations