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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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Matheus Moreira Perez

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Open access Sep 2026

MDL-800-induced SIRT6 activation decreases age-associated osteoarthritis in mice.

OBJECTIVE SIRT6 is a nuclear-localized histone deacetylase that regulates multiple pathways associated with aging. This study aimed to determine whether systemic administration of a small molecule activator of SIRT6, MDL-800, decreases the severity of age-associated osteoarthritis (OA) in mice. METHODS Male 18-month-...

Matheus Moreira Perez, Pranay Ramteke, Bahiyah Watson et al. · 0 citations

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