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Mathew A. Coban

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Review Open access Sep 2026

Friend or Foe? Unraveling the Dual Role of MMP-12 in Cancer Biology

Matrix metalloproteinases (MMPs) have long been recognized as key mediators of tumor invasion and metastasis due to their capacity to degrade extracellular matrix components. However, clinical failure of broad-spectrum MMP inhibitors has revealed a more complex and context-dependent role for these proteases in cancer....

Alireza Shoari, Mathew A. Coban · 0 citations

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