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Author

Mathias Vormehr

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Open access Sep 2026

Messenger RNA delivery of a dual CD25/CD122 affinity-tuned IL-2 variant prolongs exposure and potentiates antitumor T cell immunity

The therapeutic potential of interleukin-2 (IL-2) in cancer treatment is limited by toxicity challenges, partly due to an unfavorable pharmacokinetic profile and unintended activation of regulatory T (Treg) cells alongside the desired activation of CD8+ effector T cells. To selectively stimulate CD8+ T cells over Treg...

Mathias Vormehr, L. Kranz, A. Muik et al. · 0 citations

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