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Author

Mathilde Roth

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Open access Jul 2026

Mechanistic Insights into Autoinhibition of the Human Flippase ATP8B1

P4-ATPases are lipid flippases that maintain membrane phospholipid asymmetry by transporting specific phospholipids from the exoplasmic to the cytosolic leaflet, an essential process for membrane integrity, trafficking and signaling. Several P4-ATPases are tightly regulated by autoinhibitory N- and C-terminal extension...

Michelle Juknaviciute Laursen, Mathilde Roth, P. Nissen et al. · 0 citations

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