Matthew E Currier

Strain-Accelerated β‑Thiolactone Native Chemical Ligation with Kinetic Control Enables Rapid and Selective Hydrogelation for Biofabrication

A central challenge in biomaterials design is developing cross-linking reactions that are fast, selective, synthetically accessible, and compatible with the nucleophile-rich environments required for cell encapsulation. Native chemical ligation (NCL) offers an attractive route to amide-linked hydrogels under mild aqueo...