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Author

Matthew H. Thomas

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4 papers indexed here

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Open access Sep 2026

Nanoemulsion adjuvanted COBRA HA vaccine enhances protective antibody titers against H1N1 and H3N2 influenza viruses

ABSTRACT Adjuvants can enhance the elicited immune responses to recombinant hemagglutinin (HA) proteins following intramuscular vaccination. In this study, computationally optimized broadly reactive antigen (COBRA) designed HA proteins were adjuvanted with the W805EC oil-in-water nanoemulsion (“NE01”) and used to vacci...

Matthew H. Thomas, Ted M. Ross · 0 citations
Open access Aug 2026

Intranasal delivery of a COBRA-based protein vaccine adjuvanted with c-di-AMP enhances breadth of protective immune responses against seasonal influenza viruses

Pentavalent COBRA HA/NA intranasal vaccination adjuvanted with c-di-AMP induced strong humoral and cellular immune responses in murine models, highlighting the value of combining broadly protective COBRA vaccine candidates with advanced mucosal adjuvants to enhance efficacy against antigenically drifted influenza virus...

Camila C. S. Caetano, David A. Prots, Matthew H. Thomas et al. · 0 citations
Open access Sep 2026

Computationally Optimized H1 and H3 Hemagglutinin Messenger RNA Vaccines Confer Broad Protective Immunity Against Modern Influenza Viruses

These findings demonstrate that COBRA HA encoding mRNA vaccines can effectively leverage immunological memory while expanding responses to conserved HA epitopes, supporting improved protection against antigenically drifted strains and represents a promising strategy for next-generation influenza vaccination.

James D. Allen, Jessica M. Medina, Camila Caetano et al. · 0 citations

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