Intermittent and extended cocaine access attenuate cocaine-vs-food choice in male and female rats.
Cocaine use disorder (CUD) can be modeled preclinically using different temporal cocaine self-administration access conditions. For example, intermittent-access (IntA) procedures typically use cycles of brief (e.g., 5 min) cocaine-access periods separated by longer (e.g., 25 min) time-outs to generate bouts of high-rat...