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Matthew S. Gentry

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Open access Aug 2026

Corpora amylacea profiling reveals disease stage and brain region-specific alterations in glycogen metabolism in Alzheimer’s disease patient brains

Corpora amylacea is profile in 230 postmortem human brains, revealing significantly higher densities in Alzheimer’s disease (AD) patients when compared with patients with other or no neurodegenerative diseases and a tight correlation of CA density with neurofibrillary tangle pathology.

Jonathan A. B. Villareal, Tim Bathe, Ana Paulina Barba De la Rosa et al. · 1 citation
Open access Jul 2026

Glycogen-Dependent Metabolic Reprogramming Regulates Microglial Activation and Dysfunction in Neurodegenerative Disease

Glycolytic inhibition of glycogenolysis blunted microglia responses to Abeta aggregates and markedly reduced Abeta uptake, confirming a functional role for glycogen metabolism in shaping microglial states and highlighting glycogen homeostasis as a potential therapeutic target for promoting Abeta clearance and preservin...

Hannah McAlister, Heather Merchant, Verity F. T. Mitchener et al. · 0 citations

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