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Matthew T. O'Neill

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Open access Aug 2026

Towards programmable metallonucleases via genetic code expansion

The potential of BpyAla-mediated nucleic acid cleavage is discussed, with emphasis on the development of next-generation BpyAla analogues, the exploration of alternative metal cofactors, cooperative and multi-residue design strategies, and the expansion of compatible protein scaffolds and nucleic acid substrates.

Eryn Lundrigan, Matthew T. O'Neill, J. P. Pezacki · 0 citations

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