Open access
Jul 2026
Novel Insights into the Human Hsc70 Structure by Cross-Linking Mass Spectrometry and Molecular Modeling
The results reveal distinct ATP- and ADP-state dimer conformations that coexist in equilibrium, and demonstrate that the Hsc70 dimer population is structurally heterogeneous and depends on nucleotide state and cochaperone interactions.
A. Melikov, Vsevolod Viliuga, Daniel Kavan et al.
· Journal of Proteome Research · 0 citations