Author

Mattia Conte

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Open access Sep 2026

Scaling of structural variability of ecDNA polymer condensates with copy number boosts and stabilises oncogene regulatory contacts

Extrachromosomal DNAs (ecDNAs) form highly heterogeneous condensates in cancer cells that drive oncogene overexpression, yet how structural variability coexists with stable gene regulation remains unclear. Here, we develop a minimal polymer physics model of MYC-harbouring COLO320-DM ecDNAs, where BRD4-like complexes bi...

Mattia Conte, Sumanta Kundu, Sougata Guha et al. · bioRxiv · 0 citations

Open access Aug 2026

Phase separation of ecDNA condensates establishes in-trans contact domains that boost selective MYC regulatory interactions

Extrachromosomal DNAs (ecDNAs) are circular DNA elements found in many human cancers, often carrying oncogenes and regulatory elements. In COLO320-DM colorectal cancer cells, MYC-harboring ecDNAs form nuclear clusters associated with oncogene overexpression, but the mechanisms underlying their aggregation and gene upre...

Mattia Conte, Lana Al Hasani, T. Matteuzzi et al. · Nature Communications · 0 citations