Author

Mattia Mori

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Open access Sep 2026

Covalent Targeting and Thermostabilization of Oncogenic R280K and R273H Mutants p53 by Small Molecule RVJB59

Breast cancer is one of the most common cancers worldwide. Approximately 30%–40% of breast cancers harbor mutations in the TP53 gene, leading to structural and functional alterations in the p53 protein. These changes result in mutant proteins that are unable to perform their canonical tumor suppressor functions and, in...

Ricardo J. F. Ferreira, L. Gonçalves, Mattia Mori et al. · ChemMedChem · 0 citations

Open access Aug 2026

Mechanistic Insights into CFTR Potentiation by the Antimicrobial Peptide Esc(1–21): Direct Interaction with the NBD1-NBD2 Interface

The first mechanistic insights into the interaction of Esc(1–21) with CFTR in a cellular context are provided and the NBD1-NBD2 interface is identified as a suitable target for peptide-based potentiators to support the development of Esc(1–21) and its derivatives as novel multifunctional therapeutic candidates for CF t...

D. Baroni, L. Ferrera, Mario Passalacqua et al. · ACS Omega · 0 citations