Author

Mauro Giacca

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Open access Sep 2026

High-throughput, high-fidelity reconstruction of whole mouse-heart cytoarchitecture at cellular scale.

Understanding the three-dimensional organisation of the myocardium requires imaging approaches that can resolve cellular structures across the entire heart. Existing methods are limited by trade-offs between spatial resolution, imaging depth and throughput. Here we present a high-throughput imaging pipeline for high-fi...

F. Giardini, C. Palandri, Sofia Botti et al. · Journal of Physiology · 0 citations

Open access Sep 2026

Atherosclerotic plaque fibroblasts derive from adventitial and medial Pdgfra-lineage-positive cells and predominantly maintain fibroblast identity.

AIMS Fibroblasts are mesenchymal cells in the healthy vascular adventitia. In atherosclerosis, single-cell sequencing datasets suggest fibroblasts are abundant in plaques. However, their identity, origin, and fate during plaque progression remain unclear, which we aim to unravel here. APPROACH AND RESULTS To robustly...

Guan-Liang Li, S. Asselberghs, Bai-Xue Yu et al. · Cardiovascular Research · 0 citations

Open access Jul 2026

Chitosan-based polyelectrolyte nanocomplexes for delivery of miRNA-199a in cardiac regeneration.

Ischemic heart disease is the main cause of death in developed countries, and full recovery remains unachievable. A potential cure can be based on utilizing miRNAs capable of triggering cardiac regeneration by stimulating cardiomyocyte proliferation. However, to deliver miRNAs efficiently, nanocarriers are required for...

H. Genedy, T. Delair, Josef Huntington et al. · International Journal of Bio... · 0 citations