Review
Open access
Sep 2026
Beyond angiogenesis: the paradoxical emerging pro-tumorigenic role of Thrombospondin-2
The tumor microenvironment is a complex ecosystem where the extracellular matrix serves as a dynamic signaling hub and regulates tumorigenesis. Thrombospondin-2 (THBS2), a matricellular extracellular matrix protein, has traditionally been regarded as an inhibitor of angiogenesis. However, emerging evidence reveals a pl...
Hetal Abhay Shah, Maushmi S. Kumar
· Frontiers in Pharmacology · 0 citations