Maxwell Frye

Parkinson's disease-linked D620N mutation selectively alters the brain-specific protein interactome of VPS35.

Mutations in several genes are known to cause familial forms of Parkinson's disease (PD), including mutations in the vacuolar protein sorting 35 ortholog (VPS35) gene linked to late-onset, autosomal dominant PD. VPS35 encodes a core subunit of the retromer complex which functions in endosomal sorting and recycling. It...