Open access
Sep 2026
Development and application of antibody framework region-targeted cross-linking mass spectrometry for epitope screening within patient-derived immune complexes.
Identification of antibody-binding epitopes on antigens is essential for understanding the pathogenic roles of immune complexes (ICs) in autoimmune diseases and for the development of diagnostics and therapeutics. However, methods for direct epitope characterization of IC-antigens formed in vivo remain limited. Here, w...
Nozomi Aibara, Ryuji Yamazawa, Yuya Matsugi et al.
· Journal of Pharmaceutical an... · 0 citations