Mayble Mary Lyngkhoi

DESIGN, SYNTHESIS, AND IN VITRO SCREENING OF MACROCYCLIC UREA-BASED HETEROCYCLIC SYSTEMS WITH UNUSUAL RING CONSTRAINTS

Macrocycles are highly privileged scaffolds in contemporary drug discovery, yet their inherent structural flexibility often imposes severe entropic penalties upon target binding. We report the rational design, synthesis, and comprehensive biological evaluation of a novel class of macrocyclic ureas that incorporate an u...