Maytus Piriyajitakonkij

Generalizing Protein Fitness Prediction Across Distribution Shifts via Structural and Co-evolutionary Priors

Protein fitness prediction is essential for protein engineering. Recent fitness-landscape benchmarks such as FLIP2 have shown that methods performing well under conventional train–test splits can fail when the test set is shifted out of distribution (OOD), including mutations at unseen positions and variants from unsee...