The endothelin system: a potential target for the treatment of type 2 diabetes mellitus and associated cardiometabolic complications.
Type 2 diabetes mellitus (T2DM) is characterized by insulin resistance (IR), metabolic dysfunction, and cardiovascular (CV) and renal complications. Endothelin-1 (ET-1) receptors are widely expressed in insulin-sensitive tissues, including adipose tissue, skeletal muscle, and liver, which are both sources and targets o...