Review
Open access
Jul 2026
Integrated Signaling Networks in Osteoarthritis and Aging: From Molecular Mechanisms to Therapeutic Targets
OA is a multi-pathway aging disorder that leads to cartilage destruction by combining the senescence-associated secretory phenotype, epigenetic dysregulation, metabolic dysfunction, and impaired mechanotransduction, and OA is a systemic aging disorder that necessitates multi-target strategies.
S. Jami, Ahmed Abu Ryash, Fayez Abidah et al.
· Voice of Doctors Journal · 0 citations