Meda Bugi

Obesity, Oxidative Stress, and Inflammation in Precocious Puberty: Do All Roads Lead to the Hypothalamus?

Childhood obesity is consistently associated with earlier pubertal timing, particularly in girls, whereas its relationship with true central precocious puberty (CPP), defined by premature activation of the hypothalamic–pituitary–gonadal (HPG) axis, is less clearly established. An increased frequency of CPP diagnoses an...