Box–Behnken Design-Based Development, Optimization, and Physicochemical Characterization of a Pregabalin-Loaded Self-Nanoemulsifying Drug Delivery System (SNEDDS) for Neuropathic Pain Management
Background: Pregabalin, a first-line agent for neuropathic pain, has physicochemical and pharmacokinetic characteristics — high aqueous solubility combined with variable, dose-dependent absorption and a short elimination half-life — that make conventional oral formulations suboptimal for sustained symptom control. Self...