Author

Megan Crumbaker

2 papers indexed here

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Open access Oct 2026

TheraPb Phase 1b: First-in-Human Dose-Escalation and Optimization Study of 212Pb-ADVC001 in PSMA-Positive Metastatic Androgen Pathway Modulation-Resistant Prostate Cancer.

[212Pb]Pb-ADVC001 (212Pb-ADVC001) is a prostate-specific membrane antigen (PSMA)-targeted radiopharmaceutical therapy with high linear energy transfer derived predominantly from the alpha-emission of its 212Pb payload which, upon decay, delivers potent ionizing radiation directly to the tumor. TheraPb (NCT05720130) is...

A. R. Hansen, D. Pattison, Jeffrey C. Goh et al. · Journal of Nuclear Medicine · 0 citations

Open access Sep 2026

Tumor-Intrinsic Blood and Imaging Correlatives in Advanced Prostate Cancer Treated with Combination Radiopharmaceutical Therapy and Immunotherapy.

The PRINCE trial showed the clinical activity for 177Lu-PSMA-617 in combination with pembrolizumab for metastatic castration-resistant prostate cancer. To refine patient selection and improve response monitoring strategies to this combination, we investigated candidate tumor-intrinsic biomarkers of treatment response a...

S. Tolmeijer, Edmond M. Kwan, Andrei Gafita et al. · Journal of Nuclear Medicine · 0 citations