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Author

Megan Sykes

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Open access Sep 2026

Spatiotemporal single-cell profiling reveals T cell clonal dynamics and phenotypic plasticity in human graft-versus-host disease

Allogeneic hematopoietic cell transplantation cures hematologic diseases but is limited by acute graft‑versus‑host disease. How human T cell clones drive epithelial injury remains poorly mapped. We studied 31 transplant recipients, integrating longitudinal T cell antigen receptor (TCR) profiling with single-cell RNA se...

Ling-Ting Shi, Ajna Uzuni, X. Wang et al. · 0 citations
Open access Jul 2026

Modeling immune responses to autologous and allogeneic human stem cell-derived islet grafts in vivo 2332710

While allogeneic grafts undergo strong immune infiltration and tissue remodeling, autologous stem cell-derived islet grafts remain largely protected, even in the presence of autoreactive T cells, indicating that additional stimuli may be required to trigger autoimmune β-cell targeting in vivo.

Giorgia Zanetti, Camillo Bechi Genzano, Sakshi Bhatele et al. · 0 citations

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