Jul 2026
Capture-SELEX-Derived Low-Nanomolar-Affinity Aptamers for Doxorubicin and Inhibition of Cellular Uptake.
This work employed capture-SELEX, which uses free target molecules in solution without immobilization, to isolate DNA aptamers that specifically recognize doxorubicin and significantly inhibited doxorubicin uptake by HeLa cells, establishing a new generation of anthracycline aptamers.
Meheta Datta, Celine Fidella, Lashaun N. Coote et al.
· ACS Chemical Biology · 0 citations