Author

Mei Chen

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Open access Sep 2026

Biphasic, Time-Dependent Roles of NK1.1⁺ Cells In Retinal Injury and Repair

To investigate the stage-specific role of NK1.1⁺ cells in two experimental models of retinal injury: laser-induced choroidal neovascularization (CNV) and retinal detachment (RD). The study used C57BL/6J mice (8–12 weeks). NK1.1 + cells were depleted either during the acute phase (< 48 h after injury) or throughou...

Xue-Xue Cui, Rui-Qi Zhou, Cai-Jiao Yi et al. · Inflammation · 0 citations

Open access Aug 2026

A Novel Ocular Fibrosis Signature for AMD Using the Two-Stage Laser-Induced Subretinal Fibrosis Mouse Model

Purpose Subretinal fibrosis is a major cause of irreversible vision loss in neovascular age-related macular degeneration (AMD), yet no effective antifibrotic therapies exist due to poorly defined molecular drivers. This study aimed to derive and validate a persistent ocular fibrosis signature using the two-stage laser-...

David Hughes, Axelle Larue, Petr Taus et al. · Investigative Ophthalmology... · 0 citations

Open access Aug 2026

The Integrin-Mediated Focal Adhesion Is Critically Involved in the Macrophage-to-Myofibroblast Transition in Subretinal Fibrosis.

Fibrosis, a common endpoint of chronic inflammatory diseases across organs, remains a major therapeutic challenge. Macrophages are central regulators of fibrotic remodeling, with evidence suggesting their direct role through macrophage-to-myofibroblast transition (MMT). However, the upstream mechanisms governing macrop...

Wen Deng, Cai-Jiao Yi, Jian Liu et al. · American Journal of Patholog... · 0 citations