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Mei-Juan Xie

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Open access Sep 2026

Targeting Ero1L by Parthenolide Alleviates Cellular Senescence and Fibrosis of Localized Scleroderma by Regulating Mitochondria‐Associated Endoplasmic Reticulum Membranes Stabilization

ABSTRACT Mitochondrial dysfunction drives scleroderma pathogenesis. The mitochondria‐associated endoplasmic reticulum membrane (MAM) regulates mitochondrial function. Parthenolide (PTL) has protective effects on mitochondria. However, its specific role and mechanisms in localized scleroderma (LoS) remain unclear. This...

Fei Wang, Run-Qing Xing, Mei-Juan Xie et al. · 0 citations

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