Integration of network pharmacology and biological validation reveals the mechanisms of alkaloids from Veratrum nigrum L. in ameliorating hypertension and vascular remodeling
Introduction: Hypertension is a major risk factor for vascular diseases. The roots and rhizomes of Veratrum nigrum L. have been used to treat hypertension with alkaloids (component A) from these plants showing potential as antihypertensive agents.Objectives: This study aims to identify the key active ingredients in...