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Mei-Jiao Zhu

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Review Open access Jul 2026

The role of NLRP3 inflammasome in age-related macular degeneration: mechanisms and therapeutic prospects

Age-related macular degeneration (AMD) is a fundus oculi disease that progressively impairs the central vision of patients. To date, its pathogenesis has not been fully elucidated, and therapeutic options for dry AMD remain limited. Recently, chronic low-grade inflammation has been recognized as an important pathogenic...

Meijiao Zhu, Weihong Yu · 0 citations
Open access Aug 2026

Single-cell spatial transcriptomics reveals rewiring of RPE and Müller glia signaling toward photoreceptors following outer segment disruption in Prph2C213Y mice.

It is indicated that PRPH2-associated retinal dystrophy is a multicellular process in which OS disruption drives coordinated RPE and Müller glial remodeling with potentially protective or pro-degenerative effects, and nominate the RPE Nfib-Fstl1 program, Müller glial AP-1 responses with predicted STAT3 involvement, and...

Haoxin Guo, Linfei Wei, Binghan Chen et al. · 0 citations

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