Open access
Jul 2026
A barrier to human embryogenesis involves dysregulated 3D genome reprogramming and ZGA collapse.
An integrated analysis of chromatin architecture and transcriptome dynamics in arrested human embryos during zygotic genome activation (ZGA) stage suggests that defective 3D genome reprogramming and transcriptomic dysregulation are associated with human embryonic arrest at the eight-cell stage.
Yue-Di Cao, Geng G. Tian, Changliang Hou et al.
· Communications Biology · 0 citations