Author

Melanie G. Kirkpatrick

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Open access Oct 2026

Astroviruses use mucus secretion as a novel form of viral egress.

Viruses rely on coordinated host pathways to exit the cell and propagate infection. We have come to appreciate that non-enveloped enteric viruses can use both lytic and non-lytic strategies to exit host cells. However, it remains unclear how astroviruses, a major causative agent of pediatric diarrhea, facilitate this f...

Natalie Pedicino, Melanie G. Kirkpatrick, Michelle Ann Pablo et al. · PLoS Pathogens · 0 citations

Open access Oct 2026

Pan-Coronavirus Protease Engagement and Differentiated Pharmacology of Antiviral Candidate CMX990

COVID-19 highlighted the need for antivirals that can be rapidly deployed against both current and future coronavirus threats. CMX990 is a clinical stage coronavirus main protease (Mpro) inhibitor bearing a unique trifluoromethoxymethyl ketone warhead. Here, we broadly evaluate its pan-coronavirus target engagement, an...

N. G. R. Dayan Elshan, Karen C. Wolff, L. Riva et al. · bioRxiv · 0 citations