Author

Mélanie Henderson

2 papers indexed here

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Sep 2026

Functional Characterization of a Novel Variant of the Thyroid Hormone Receptor Alpha in a Child with Developmental Delay and Abnormal Thyroid Function.

BACKGROUND Resistance to thyroid hormone α (RTHα) is a rare disorder caused by pathogenic THRA variants. We investigated the molecular basis of RTHα in a child with developmental delay, dysmorphic features, and a suggestive biochemical profile. METHODS Whole-exome sequencing identified a de novo THRA variant. Cell-ba...

V. Caron, K. Bonnycastle, Agathe Rio et al. · Thyroid · 0 citations

Open access Oct 2026

Device-Measured Physical Activity, Sedentary Time, and Cardiometabolic Risk Markers in Youth: A Harmonized Individual Participant Data Meta-Analysis.

Importance The evidence for benefits of higher physical activity and lower sedentary time on the cardiometabolic risk profile in youth is based on cross-sectional and small prospective studies. Objective To determine the prospective associations between device-measured physical activity and sedentary time with later...

Anders Husøy, K. Dalene, B. H. Hansen et al. · JAMA pediatrics · 0 citations