Author

Mélanie Munch

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Open access Jul 2026

Machine Learning-Guided Engineering of High-Affinity Cross-Reactive Antibodies with Minimal Mutations

A Deep Mutational Scanning-coupled deep learning strategy to engineer potent cross-reactive antibodies with minimal sequence divergence that retained PD-1/PD-L1 blockade and demonstrated therapeutic activity in a mouse tumor model is developed.

H. Dorison, Anne-Laure Grindel, François Thenier et al. · bioRxiv · 0 citations