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Author

Melanie Weilert

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Open access Oct 2026

High-resolution binding data of TFIID and cofactors show promoter-specific differences

TFIID is instrumental in recognizing promoter sequences and initiating transcription, yet a cohesive understanding of how this complex engages and functions at different promoter types in vivo is still lacking. Here, we employed ChIP-nexus to capture high-resolution binding footprints of all Drosophila TFIID subu...

Sergio G.-M. Alcantara, Simon Bourdareau, Melanie Weilert et al. · 0 citations
Open access Sep 2026

AlphaGenome Atlas: in silico mutagenesis of the entire human genome improves prioritization and interpretation of non-coding variants

A major challenge in genomics is deciphering the functional consequences of non-coding genetic variation. Here we present AlphaGenome Atlas, a comprehensive resource that enables the joint interpretation and prioritization of variant effects across the entire human genome. Using AlphaGenome, we predicted the regulatory...

Jun Cheng, Kyle R. Taylor, Lauren Nicolaisen et al. · 3 citations · ⚡1

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