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Author

Melanie Wittner

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Open access Jul 2026

CD96 marks a phenotypically distinct checkpoint-associated HCV-specific CD8+ T-cell subset featuring memory-associated states

Introduction Hepatitis C virus (HCV) infection frequently progresses to chronicity, where persistent antigen exposure drives differentiation of virus-specific CD8+ T cells toward an exhausted phenotype. This state is defined by progressive upregulation of inhibitory receptors and functional impairment of antigen-specif...

M. Knapp, C. Ackermann, Melanie Wittner et al. · 0 citations

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