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Author

Men Thi Hoai Duong

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Open access Sep 2026

Mutations in the macrodomain 1 of nsp3 attenuate PEDV virulence in vivo without impairing in vitro replication

This work provides the first in vitro and in vivo evidence that the conserved N462 residue in the PEDV Mac1 domain is critical for both ADP-ribose binding and hydrolysis, induces IFN production, and contributes to virulence.

Ming-De Liu, Men Thi Hoai Duong, Thamonpan Laocharoensuk et al. · 0 citations

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