Author

Meng-Jie Zheng

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Open access Oct 2026

Integrated transcriptomic, machine learning, and network pharmacology analyses reveal shared inflammatory biomarkers between intervertebral disc degeneration and osteoporosis

Intervertebral disc degeneration (IDD) and osteoporosis (OP) frequently coexist, but their shared inflammatory molecular features remain unclear. We investigated whether the two disorders share an immune-extracellular matrix axis and sought candidate inflammation-associated biomarkers. Public transcriptomic...

Meng-Jie Zheng, Gui-Zhi Zhu, Hong-De Jiang et al. · Frontiers in Immunology · 0 citations

Open access Sep 2026

Genetically informed prioritization of immune checkpoint–associated genes in head and neck cancer highlights HGF and AKT1

Immune checkpoint inhibitors are used to treat head and neck cancer (HNC), but clinical responses vary, and systematic genetic evaluation is needed to prioritize candidate susceptibility genes. We applied summary-data-based Mendelian randomization (SMR) and HEIDI testing to screen 624 immune checkpoint–related genes, i...

Meng-Jie Zheng, Hao Zhu, Jun Kong et al. · Functional & Integrative Gen... · 0 citations