Author

Mengkai Lu

3 papers indexed here

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Open access Sep 2026

Salvianolic Acid a Disrupts the HSP90α‐AKT‐PERK Ternary Complex to Alleviate Atherosclerosis by Activating Endoplasmic Reticulum Stress of Senescent Vascular Smooth Muscle Cells

ABSTRACT Atherosclerosis is a chronic inflammatory disease driven by senescent vascular smooth muscle cells (VSMCs). Salvianolic acid A (SAA) exhibits cardiovascular protective effects; however, its role in atherosclerosis remains unclear. This study aimed to investigate the effects and targets of SAA in atherosclerosi...

Xiu-Ya Guan, Meng-Kai Lu, Xin-Hai Cui et al. · Advancement of science · 0 citations

Review Open access Oct 2026

Vascular Smooth Muscle Cell Plasticity in Atherosclerosis: From Macrophage-like Transdifferentiation to Therapeutic Targeting

Atherosclerosis remains the leading cause of cardiovascular mortality worldwide. Vascular smooth muscle cells (VSMCs) were long regarded as passive structural elements of the arterial wall, but they are now recognized as highly plastic cells capable of transdifferentiating into macrophage-like cells (MLCs). This conver...

Mu-Xin Zhang, Zi-Cheng Wang, Meng-Kai Lu et al. · International Journal of Mol... · 0 citations

Open access Aug 2026

TEK Downregulation Of LOX Propeptide: A Novel Mechanism For Endothelial Cell Protection Following Myocardial Infarction.

A novel interaction between TEK receptor tyrosine kinase (TEK) and signal transducer and activator of transcription 3 (STAT3) is identified, promoting the phosphorylation and nuclear translocation of STAT3 and preventing the upregulation of STAT3 and p-STAT3.

Chao Li, Muxin Zhang, Meng-Kai Lu et al. · Pharmacological Research · 0 citations